abstract：:The centrally mediated pharmacological effects of thyrotropin releasing hormone (TRH), their mechanistic basis and therapeutic implications, along with the possible physiological significance of extrahypothalamic TRH, have been the subject of numerous investigations for over a decade. Despite this effort a holistic pe...

journal_title：Life sciences

authors： Yarbrough GG

更新日期：1983-07-11 00:00:00

abstract：:In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...

journal_title：Life sciences

authors： Cullen EI,Medzihradsky F

更新日期：1983-07-11 00:00:00

abstract：:The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...

journal_title：Life sciences

authors： McPherson GA,Summers RJ

更新日期：1983-07-04 00:00:00

abstract：:The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...

journal_title：Life sciences

authors： Sugio K,Daly JW

更新日期：1983-07-04 00:00:00

abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...

journal_title：Life sciences

authors： Gole JW,Orr GL,Downer RG

更新日期：1983-06-27 00:00:00

abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...

journal_title：Life sciences

authors： Matlib MA,Schwartz A

更新日期：1983-06-20 00:00:00

abstract：:Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...

journal_title：Life sciences

authors： Puvion-Dutilleul F,Puvion E,Macieira-Coelho A

更新日期：1983-06-13 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：:The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...

journal_title：Life sciences

authors： Mosberg HI,Hurst R,Hruby VJ,Galligan JJ,Burks TF,Gee K,Yamamura HI

更新日期：1983-05-30 00:00:00

abstract：:This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained porti...

journal_title：Life sciences

authors： Theobald RJ Jr

更新日期：1983-05-23 00:00:00

abstract：:The effects of naloxone, an opiate "pure" receptor antagonist, on the release of prolactin and corticosterone in the rat were studied following the administration of the serotonin precursor 5-hydroxytryptophan or the serotonin receptor agonist (-) -m-chlorophenylpiperazine. Naloxone clearly antagonizes the release of ...

journal_title：Life sciences

authors： Preziosi P,Cerrito F,Vacca M

更新日期：1983-05-23 00:00:00

abstract：:We have developed an assay for serotonin (5-HT) stimulation of adenylate cyclase activity in membranes from adult guinea pig hippocampus. The response to 5-HT is concentration-dependent, with an EC50 of 0.01 microM, a shallow slope, and mean maximal stimulation of 90% over basal activity. The response to 5-HT is GTP-d...

journal_title：Life sciences

authors： Shenker A,Maayani S,Weinstein H,Green JP

更新日期：1983-05-16 00:00:00

abstract：:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effe...

journal_title：Life sciences

authors： MacMurray JP,Barker JP,Armstrong JD,Bozzetti LP,Kuhn IN

更新日期：1983-05-16 00:00:00

abstract：:The presence of met5-enkephalin-arg6-phe7 (YGGFMRF) and opiate receptors in rat, guinea pig and human lung was investigated with specific and sensitive radio immuno- and radio-receptor assays. 1) High and low molecular weight YGGFMRF-like immunoreactivity were detected in lung extracts using Bio-Gel P-2 column chromat...

journal_title：Life sciences

authors： Tang J,Chou J,Zhang AZ,Yang HY,Costa E

更新日期：1983-05-16 00:00:00

abstract：:Phospholipid-sensitive Ca2+-dependent protein kinase and its endogenous substrate proteins were examined in acinar cells from rat pancreas. The enzyme was clearly demonstrable by DEAE-cellulose chromatography of acinar cell extract. At least four endogenous substrate proteins (Mr = 38K, 30K, 22K and 15K) for this Ca2+...

journal_title：Life sciences

authors： Wrenn RW

更新日期：1983-05-16 00:00:00

abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...

journal_title：Life sciences

authors： Weber RE,Wells RM,Tougaard S

更新日期：1983-05-02 00:00:00

abstract：:This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...

journal_title：Life sciences

authors： Dubey AK,Herbert J,Martensz ND,Beckford U,Jones MT

更新日期：1983-04-18 00:00:00

abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...

journal_title：Life sciences

authors： Lackovic Z,Neff NH

更新日期：1983-04-11 00:00:00

abstract：:Static sense organs composed of a hollow statocyst surrounded by sensory hairs and containing aggregate bodies (statoliths) have been detected in various species of Vespinae. On the frons in the groove traversing its center (the frontal groove) there is a deep pit and around it a membrane enclosing a cyst-like sac. In...

journal_title：Life sciences

authors： Ishay JS,Shimony T,Arcan L

更新日期：1983-04-11 00:00:00

abstract：:By use of ion exchange chromatography we have isolated two discrete classes of "free" glycosaminoglycans (GAG) from human plasma. The GAG fractions were tested for their effects on two lipoprotein lipase (LPL) enzyme systems containing an apolipoprotein C-II activated emulsion as the triglyceride substrate and bovine ...

journal_title：Life sciences

authors： Felts JM,Staprans I,Gorman RA

更新日期：1983-04-04 00:00:00

abstract：:Liquid protein diet (LPD) has been shown previously to produce maternal and fetal weight loss and fetal congenital anomalies, including cataracts and craniofacial malformations. Therefore, to examine the effects of LPD in pregnancy upon the central nervous system of pups, pregnant dams were fed either a 20% casein die...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-04-04 00:00:00

abstract：:The metabolic capability of hepatocytes prepared by the perfusion method (P cells) and the tissue slice method (S cells) has been compared using standardised procedures. Yields of P cells were four times greater than for S cells. Trypan blue exclusion viability and oxygen utilization were similar although the viabilit...

journal_title：Life sciences

authors： Sturdee AP,Beirne JM,Sörman AE,Orton TC,Crisp DM

更新日期：1983-03-28 00:00:00

abstract：:The accumulation of lysophosphoglycerides has been implicated as an important biochemical factor for cardiac arrhythmias. Recently, we demonstrated that lysophosphatidylcholine caused cardiac arrhythmias in the isolated hamster heart. In this study, the arrhythmogenic nature of various lysophosphoglycerides with respe...

journal_title：Life sciences

authors： Man RY,Wong T,Choy PC

更新日期：1983-03-21 00:00:00

abstract：:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...

journal_title：Life sciences

authors： Tritsch GL,Niswander PW

更新日期：1983-03-21 00:00:00

abstract：:Benzodiazepines reliably produce overconsumption of food and fluids. Opiate antagonists, naloxone and naltrexone, block the benzodiazepine-induced hyperphagia and hyperdipsia at low doses. Hence, activation of endogenous opioid mechanisms may be closely involved in the benzodiazepine facilitatory effects on ingestiona...

journal_title：Life sciences

authors： Cooper SJ

更新日期：1983-03-07 00:00:00

abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...

journal_title：Life sciences

authors： Mazurkiewicz-Kwilecki IM

更新日期：1983-03-07 00:00:00

abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...

journal_title：Life sciences

authors： Surwit RS,Allen LM 3rd,Gilgor RS,Schanberg S,Kuhn C,Duvic M

更新日期：1983-02-28 00:00:00

abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...

journal_title：Life sciences

authors： Meltzer HY,Mikuni M,Simonovic M,Gudelsky GA

更新日期：1983-02-28 00:00:00

abstract：:Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...

journal_title：Life sciences

authors： George MH,Leitch GJ

更新日期：1983-02-21 00:00:00

abstract：:Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Martin GE,Chen TB

更新日期：1983-02-21 00:00:00

abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...

journal_title：Life sciences

authors： Nakadate T,Nakaki T,Yamamoto S,Kato R

更新日期：1983-02-14 00:00:00

abstract：:A sensitive and specific radioimmunoassay for substance P has been developed and its full characterisation is described. The assay was used to investigate the stability of substance P in tissue in order to establish the optimal conditions of tissue storage for maximal recovery of the peptide. The results indicate unex...

journal_title：Life sciences

authors： McGregor GP,Bloom SR

更新日期：1983-02-07 00:00:00

abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...

journal_title：Life sciences

authors： Takeda Y,Itoh H,Kobashi K

更新日期：1983-01-31 00:00:00

abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

journal_title：Life sciences

authors： Koo A,Wong TM

更新日期：1983-01-31 00:00:00

abstract：:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/k...

journal_title：Life sciences

authors： Byrd LD

更新日期：1983-01-24 00:00:00

abstract：:Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...

journal_title：Life sciences

authors： Bennett WM,McDougall J,Potocnik S,Wright RD,Whitworth JA

更新日期：1983-01-17 00:00:00

abstract：:The distribution of immunoreactive-dynorphin (ir-Dyn) in isolated subpopulations of bovine adrenal chromaffin cells was examined and compared with that of adrenaline (A), noradrenaline (NA) and ir-Leucine-Enkephalin (ir-Leu-Enk). Using a stepwise bovine serum albumin (BSA) gradient, various populations of catecholamin...

journal_title：Life sciences

authors： Dumont M,Day R,Lemaire S

更新日期：1983-01-17 00:00:00

abstract：:The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component. Monoclonal antibodies have been developed against soluble thyroid TSH receptor preparations and using Graves' lymphocytes. These show that initial recognition of thyrotropin requires the glycoprotein component, but that mo...

journal_title：Life sciences

authors： Kohn LD,Valente WA,Laccetti P,Cohen JL,Aloj SM,Grollman EF

更新日期：1983-01-03 00:00:00

abstract：:The effects of the benzodiazepines diazepam and midazolam on the rigidity produced by systemic administration of morphine (15 mg/kg i.p.) were studied in rats. The rigidity was recorded as a tonic activity from the gastrocnemius-soleus muscle of non-anesthetized rats in the electromyogram. Both diazepam (1-5 mg/kg i.p...

journal_title：Life sciences

authors： Turski L,Havemann U,Kuschinsky K

更新日期：1983-01-01 00:00:00

abstract：:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...

journal_title：Life sciences

authors： Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius L

更新日期：1983-01-01 00:00:00